Thursday 22 September 2016

Combivent Respimat


See also: Generic Combivent


Combivent Respimat is a brand name of albuterol/ipratropium, approved by the FDA in the following formulation(s):


COMBIVENT RESPIMAT (albuterol sulfate; ipratropium bromide - spray, metered; inhalation)



  • Manufacturer: BOEHRINGER INGELHEIM

    Approval date: October 7, 2011

    Strength(s): EQ 0.1MG BASE/INH;0.02MG/INH [RLD]

Has a generic version of Combivent Respimat been approved?


No. There is currently no therapeutically equivalent version of Combivent Respimat available.


Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Combivent Respimat. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents


Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.




  • Nozzle assembly for preventing back-flow
    Patent 5,405,084
    Issued: April 11, 1995
    Inventor(s): Weston; Terence E. & Dunne; Stephen T.
    Assignee(s): DMW (Technology) Limited
    A nozzle assembly which comprises a nozzle aperture for discharge of a fluid as a spray of droplets, and a conduit in fluid flow communication with the nozzle aperture. The flow of fluid through the conduit is restricted by the minimum effective cross-sectional area of the conduit transverse to the line of flow of fluid through the conduit so that back flow of fluid from the nozzle aperture through the conduit at ambient and operational pressure differentials is substantially prevented. The invention further provides for a method of discharging a fluid as a spray of droplets, and a spray generating device which includes the nozzle assembly of the present invention.
    Patent expiration dates:

    • April 11, 2012
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      Drug product




  • Atomising nozzle and filter and spray generation device
    Patent 5,472,143
    Issued: December 5, 1995
    Inventor(s): Bartels; Frank & Bachtler; Wulf & Dunne; Stephen T. & Eicher; Joachim & Freund; Bernhard & Hart; William B. & Lessmoellmann; Christoph
    Assignee(s): Boehringer Ingelheim International GmbH
    DMW (Technology) Ltd.
    A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members joined together. In one of the two members are formed one or more nozzle outlets, one or more fluid inlets, and a plurality of channels that form filter passageways. The nozzle outlets discharge fluid jets that impinge on one another to thereby atomize the fluid. Alternatively, an impact element or a vortex-generating structure can be used in the nozzle outlet to atomize the fluid.
    Patent expiration dates:

    • September 29, 2013
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      Drug product




  • Atomising devices and methods
    Patent 5,497,944
    Issued: March 12, 1996
    Inventor(s): Weston; Terence E. & Dunne; Stephen T.
    Assignee(s): DMW (Technology) Limited
    A metered dose inhaler for dispensing a fluid medicament as droplets of small mean particle size without the use of pressurized gas or liquefied propellants. A liquid drug is contained in a fluid reservoir, and metered quantities of the drug are successively presented into a reduced cross-section pressure chamber, with non-return valves controlling the flow of liquid through the device. The metered quantity of the drug is then subjected to a sudden and great increase in pressure by releasing a piston into the pressure chamber. The liquid drug is thereby ejected through an atomizing head, to reduce it to a fine atomized spray of small mean particle size, preferably less than approximately 12 micrometers.
    Patent expiration dates:

    • March 12, 2013
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      Drug product




  • Atomizing devices and methods
    Patent 5,662,271
    Issued: September 2, 1997
    Inventor(s): Weston; Terence Edward & Dunne; Stephen Terence
    Assignee(s): Boehringer Ingelheim International GmbH
    A metered dose inhaler comprises a piston which is mounted in a cavity within a body, and is urged by a pre-loaded spring into a reduced cross-section pressure chamber. The piston may be loaded by means of an actuating rod having a handle, and may be latched in a loaded position by a latching means. A liquid drug (e.g. in aqueous solution) is contained in a collapsible bag. Metered quantities of the drug are successively presented in the pressure chamber, and then subjected to a sudden and great increase in pressure, to eject the liquid drug through an atomising head, to reduce it to fine atomised spray of small mean particle size--for example less than 30 micrometers. Non-return valves control the flow of liquid through the device. The sudden pressure pulse is caused be releasing the spring loaded piston, upon depressing an actuating button connected by the latching means.
    Patent expiration dates:

    • September 2, 2014
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      Drug product




  • Atomizing nozzle and filter and spray generating device
    Patent 5,911,851
    Issued: June 15, 1999
    Inventor(s): Bartels; Frank & Bachtler; Wulf & Dunne; Stephen Terence & Eicher; Joachim & Freund; Bernhard & Hart; William Barrie & Lessmoellmann; Christoph
    Assignee(s): Boehringer Ingelheim International GmbH
    A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members joined together. In one of the two members are formed one or more nozzle outlets, one or more fluid inlets, and a plurality of channels that form filter passageways. The nozzle outlets discharge fluid jets that impinge on one another to thereby atomize the fluid. Alternatively, an impact element or a vortex-generating structure can be used in the nozzle outlet to atomize the fluid. Methods are also provided for producing the nozzle assembly by forming the inlets, outlets, and/or channels through electrical or chemical etching or other processes that selectively remove material from at least one face of a nozzle assembly member.
    Patent expiration dates:

    • September 29, 2013
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      Drug product




  • Device for producing high pressure in a fluid in miniature
    Patent 5,964,416
    Issued: October 12, 1999
    Inventor(s): Jaeger; Joachim & Cirillo; Pasquale & Eicher; Joachim & Geser; Johannes
    Assignee(s): Boehringer Ingelheim GmbH
    A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.
    Patent expiration dates:

    • October 4, 2016
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      Drug product




  • Atomizing nozzle and filter and spray generating device
    Patent 6,007,676
    Issued: December 28, 1999
    Inventor(s): Bartels; Frank & Bachtler; Wulf & Dunne; Stephen Terance & Eicher; Joachim & Freund; Bernhard & Hart; William Barrie & Lessmoellmann; Christoph
    Assignee(s): Boehringer Ingelheim International GmbH
    A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a first one of the members to form, in cooperation with the generally planar surface of the second of the members, a plurality of filter passageways. A plenum chamber is formed in the first member. The plenum chamber is in fluid communication with and downstream of the plurality of filter passageways. A second set of channels is formed in the generally planar surface of the first member to form, in cooperation with the generally planar surface of the second member, a plurality of nozzle outlet passageways. These nozzle outlet passageways are in fluid communication with the plenum chamber. The nozzle outlet passageways include a plurality of nozzle outlets which are adapted to discharge a plurality of fluid jets that impinge on one another to thereby atomize a flow of fluid.
    Patent expiration dates:

    • September 29, 2013
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      Drug product




  • Mechanical counter for a metering apparatus
    Patent 6,149,054
    Issued: November 21, 2000
    Inventor(s): Cirrillo; Pasquale & Eicher; Joachim & Fiol; Andreas
    Assignee(s): Boehringer Ingelheim International GmbH
    A metering apparatus for metering for example a medicament requires a device with which the number of metering portions is displayed. The known display devices however are not suitable for a metering apparatus having two housing portions which are rotatable relative to each other. The mechanical counter for a metering apparatus of that kind comprises at least one spindle with rotary locking, whose axis extends in parallel relationship with the axis of the metering apparatus and which is disposed in the region of a peripheral surface of the apparatus. The spindle is automatically driven by way of a transmission assembly when the metering apparatus is actuated. The number of metering portions already discharged and the number of petering portions permitted in total is quasi-continuously displayed by the mechanical counter. The transmission ration of the transmission assembly can be designed to cover a wide range. The cursor serving for display purposes can be reset on the spindle. The permissible period of use of a metering apparatus which can be used for a plurality of supply containers can be reliably viewed.
    Patent expiration dates:

    • December 19, 2016
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      Drug product




  • Device for mounting a component exposed to a pressurized fluid
    Patent 6,176,442
    Issued: January 23, 2001
    Inventor(s): Eicher; Joachim & Geser; Johannes
    Assignee(s): Boehringer Ingelheim International GmbH
    The mounting of a component subjected to pressure from a fluid requires special precautions if the component is made of wear resistant, hard and hence generally brittle material and may be destroyed by locally raised stresses. A fluidic component of this kind, made, for example, of silicon/glass is arranged in an elastomeric shaped component, made, for example, of silicon rubber. The inner contours of the elastomeric shaped component correspond to the outer contours of the fluidic component. The outer contours of the shaped component corresponds to the inner contours of a holder. Due to this "floating mounting" there are no unacceptable local pressure peaks and no deformation of the fluidic component. The device is particularly suitable for mounting a fluidic component made of glass or silicon, or miniature dimensions, subject to high pressure.
    Patent expiration dates:

    • October 4, 2016
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      Drug product




  • Locking mechanism for a spring-actuated device
    Patent 6,453,795
    Issued: September 24, 2002
    Inventor(s): Joachim; Eicher & Michael; Schyra & Richard; Forster
    Assignee(s): Boehringer Ingelheim International GmbH
    A spring-actuated output drive device is used for example in medical aerosol therapy for a miniaturised high-pressure producing device for atomising a small dose of a liquid medicament. A locking-stressing-mechanism for such an output d rive device is to be stressed with the application of a relatively small amount of force and is to be released with one hand and is to operate reliably over a prolonged period of time. The locking-stressing-mechanism comprises a force step-up transmission, for example a screw thrust transmission for stressing the spring, an annularly arranged locking member with engaging locking surfaces, two abutments for limiting the travel of the spring and a release button. It is compact, economical to produce, easy to assemble and comprises components with a low rate of wear. It can be reliably and easily handled by unskilled persons, even when high spring forces are involved. A medicament to be atomised can thus be metered with a very high degree of accuracy.
    Patent expiration dates:

    • December 5, 2016
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      Drug product




  • Atomizing nozzle an filter and spray generating device
    Patent 6,503,362
    Issued: January 7, 2003
    Inventor(s): Frank; Bartels & Wulf; Bachtler & Stephen Terence; Dunne & Joachim; Eicher & Bernhard; Freund & William Barrie; Hart & Christoph; Lessmoellmann
    Assignee(s): Boehringer Ingelheim International GmbH
    A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a first one of the members to form, in cooperation with the generally planar surface of the second of the members, a plurality of filter passageways. A plenum chamber is formed in the first member. The plenum chamber is in fluid communication with and downstream of the plurality of filter passageways. A second set of channels is formed in the generally planar surface of the first member to form, in cooperation with the generally planar surface of the second member, a plurality of nozzle outlet passageways. These nozzle outlet passageways are in fluid communication with the plenum chamber. The nozzle outlet passageways include a plurality of nozzle outlets which are adapted to discharge a plurality of fluid jets that impinge on one another to thereby atomize a flow of fluid.
    Patent expiration dates:

    • September 29, 2013
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      Drug product




  • Device for producing high pressure in a fluid in miniature
    Patent 6,726,124
    Issued: April 27, 2004
    Inventor(s): Joachim; Jaeger & Pasquale; Cirillo & Joachim; Eicher & Johannes; Geser & Bernhard; Freund & Bernd; Zierenberg
    Assignee(s): Boehringer International GmbH
    A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.
    Patent expiration dates:

    • October 4, 2016
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      Drug product




  • Microstructured filter
    Patent 6,846,413
    Issued: January 25, 2005
    Inventor(s): Kadel; Klaus & Geser; Johannes & Eicher; Joachin & Freund; Bernhard & Dunne; Stephen Terence & Bachtler; Wulf
    Assignee(s): Boehringer Ingelheim International GmbH
    A microstructured filter for a fluid, the filter having an inlet for unfiltered fluid and an outlet for filtered fluid, the filter comprising: a plurality of projections (7) which are arranged in at least two rows (3) in mutually juxtaposed relationship and which project out of a base plate (1) and which are an integral component of the base plate, a plurality of passages (8) between the projections (7), and a cover plate which is securable to the base plate to cover the projections (7) and the passages (8), wherein the passages form a plurality of through paths from the inlet to the outlet, said inlet comprises an elongate inlet slot (5) for the unfiltered fluid, which extends over approximately the entire filter width and which is approximately as high as the projection (7) projecting out of the base plate, on the outlet side of the filter. The filter according to the invention remains operational, even if a part of the filter area is obstructed. The filter is used for example in an atomizer with which an aerosol is produced from a fluid which contains a medicament.
    Patent expiration dates:

    • August 28, 2018
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      Drug product




  • Microstructured filter
    Patent 6,977,042
    Issued: December 20, 2005
    Inventor(s): Kadel; Klaus & Geser; Johannes & Eicher; Joachim & Freund; Bernhard & Dunne; Stephen Terence & Bachtler; Wulf
    A microstructured filter having an inlet for unfiltered fluid; an outlet for filtered fluid; a plurality of projections which are arranged in at least two rows in mutually juxtaposed relationship, project out of a base plate and are an integral component of the base plate; a plurality of passages between the projections and a cover plate which is securable to the base plate to cover the projections and the passages. The passages form a plurality of through paths from the inlet to the outlet. The inlet includes an elongate inlet slot for the unfiltered fluid that extends over approximately the entire filter width and is approximately as high as the projection on the outlet side of the filter.
    Patent expiration dates:

    • August 28, 2018
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      Drug product




  • Cartridge for a liquid
    Patent 6,988,496
    Issued: January 24, 2006
    Inventor(s): Eicher; Joachim & Geser; Johannes & Hausmann; Matthias & Schyra; Michael & Wuttke; Gilbert & Fiol; Andreas & Kladders; Heinrich & Hochrainer; Dieter & Zierenberg; Bernd
    Assignee(s): Boehringer Ingelheim International GmbH
    For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmacologically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
    Patent expiration dates:

    • February 23, 2020
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      Drug product




  • Device for producing high pressure in a fluid in miniature
    Patent 7,104,470
    Issued: September 12, 2006
    Inventor(s): Jaeger; Joachim & Cirillo; Pasquale & Eicher; Joachim & Geser; Johannes & Freund; Bernhard & Zierenberg; Bernd
    Assignee(s): Boehringer Ingelheim International GmbH
    A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.
    Patent expiration dates:

    • October 4, 2016
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      Drug product




  • Atomising nozzle and filter and spray generating device
    Patent 7,246,615
    Issued: July 24, 2007
    Inventor(s): Bartels; Frank & Bachtler; Wulf & Dunne; Stephen T & Eicher; Joachim & Freund; Bernhard & Hart; William B & Lessmoellmann; Christoph
    Assignee(s): Boehringer International GmbH
    A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a first one of the members to form, in cooperation with the generally planar surface of the second of the members, a plurality of filter passageways. A plenum chamber is formed in the first member. The plenum chamber is in fluid communication with and downstream of the plurality of filter passageways. A second set of channels is formed in the generally planar surface of the first member to form, in cooperation with the generally planar surface of the second member, a plurality of nozzle outlet passageways. These nozzle outlet passageways are in fluid communication with the plenum chamber. The nozzle outlet passageways include a plurality of nozzle outlets which are adapted to discharge a plurality of fluid jets that impinge on one another to thereby atomize a flow of fluid.
    Patent expiration dates:

    • May 31, 2016
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      Drug product




  • Piston-pumping system having o-ring seal properties
    Patent 7,284,474
    Issued: October 23, 2007
    Inventor(s): Eigemann; Jutta & Geser; Johannes
    Assignee(s): Boehringer Ingelheim International GmbH
    The present invention relates to a piston pumping system for substantially gas-free measurement and/or pumping of predetermined quantities of liquids, preferably pharmaceutical liquids containing oxidation-prone ingredients. Preferably, the system is used as a micropump or as a component thereof in medical devices such as transdermal therapeutic systems, for example.
    Patent expiration dates:

    • August 26, 2024
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      Drug product




  • Blocking device for a locking stressing mechanism having a spring-actuated output drive device
    Patent 7,396,341
    Issued: July 8, 2008
    Inventor(s): Schyra; Michael & Wachtel; Herbert
    Assignee(s): Boehringer Ingelheim International GmbH
    A locking-stressing-mechanism with spring-actuated output drive and a counter with which an apparatus of this kind is fitted, accommodated in a two part housing the two parts of which are mounted to be rotatable relative to each other, can be blocked by means of a pre-stressed leaf spring. The leaf spring is initially accommodated in a recess in the wall of one housing part. As soon as the permitted number of actuations has been reached a push rod pushes the leaf spring out of its resting position. The leaf spring then jumps into a recess in the wall of the other housing part and the two housing parts can no longer be rotated relative to each other. The push rod may be mounted on the pointer of the counter. This blocking device can only be overcome by the application of a force which is sufficient to destroy the device. The device is suitable for blocking a high pressure atomiser or a needleless injector with which a fluid is atomised to form an aerosol or a fluid is injected into a biological tissue.
    Patent expiration dates:

    • October 10, 2026
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      Drug product




  • Cartridge for a liquid
    Patent 7,802,568
    Issued: September 28, 2010
    Inventor(s): Eicher; Joachim & Geser; Johannes & Hausmann; Matthias & Schyra; Michael & Wuttke; Gilbert & Fiol; Andreas & Kladders; Heinrich & Hochrainer; Dieter & Zierenberg; Bernd
    Assignee(s): Boehringer Ingelheim International GmbH
    For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
    Patent expiration dates:

    • February 26, 2019
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      Drug product




  • Device for clamping a fluidic component
    Patent 7,837,235
    Issued: November 23, 2010
    Inventor(s): Geser; Johannes & Hausmann; Matthias
    Assignee(s): Boehringer Ingelheim International GmbH
    A fluidic component is arranged in an elastomeric shaped part, the contour of which is matched to the outer contour of the component and to the inner contour of a holder. The elastomeric shaped part is chamfered towards the fluidic component on its pressure side. When the holder is assembled, the elastomeric shaped part is deformed by a projection provided on a mating part and is put under uniformly distributed internal tension, after which the elastomeric shaped part surrounds the fluidic component to its full height.
    Patent expiration dates:

    • March 13, 2028
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      Drug product




  • Microstructured high pressure nozzle with built-in filter function
    Patent 7,896,264
    Issued: March 1, 2011
    Inventor(s): Eicher; Joachim & Geser; Johannes & Hausmann; Matthias & Reinecke; Holger
    Assignee(s): Boehringer Ingelheim International GmbH
    A microstructured nozzle consists of a number of channels produced by microstructuring a plate-shaped member. In the nozzle the channels are located between projections which are arranged side by side in rows and project from a base plate. This microstructured base plate is covered with a cover plate. The channels are narrowly defined in terms of shape, cross sectional area and length. The nozzle contains a filter as the primary structure and a secondary structure downstream of the filter. The nozzle is used, for example, with an atomiser which produces an aerosol from a fluid containing a medicament.
    Patent expiration dates:

    • May 26, 2025
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      Drug product




  • Container provided with a pressure equalization opening
    Patent 7,988,001
    Issued: August 2, 2011
    Inventor(s): Kuehn; Torsten & Metzger; Burkhard Peter
    Assignee(s): Boehringer Ingelheim Pharma GmbH & Co. KG
    A process for producing a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and a container produced according to this process, is described, wherein a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process forms a pressure equalisation opening in the outer container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are achieved. To do this, the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.
    Patent expiration dates:

    • August 4, 2021
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      Drug product



Related Exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

  • Exclusivity expiration dates:
    • October 7, 2014 - NEW PRODUCT

See also...

  • Combivent Respimat Advanced Consumer Information (Micromedex)
  • Albuterol/Ipratropium Aerosol Consumer Information (Wolters Kluwer)
  • Albuterol/Ipratropium Solution Consumer Information (Wolters Kluwer)
  • Albuterol and ipratropium inhalation Consumer Information (Cerner Multum)
  • Ratio-Ipra Sal Udv Advanced Consumer Information (Micromedex)
  • Ipratropium and albuterol Inhalation, oral/nebulization Advanced Consumer Information (Micromedex)
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